\contentsline {section}{\numberline {1}Study Background \& Objectives}{3}{section.1}%
\contentsline {subsection}{\numberline {1.1}Study Design}{3}{subsection.1.1}%
\contentsline {subsection}{\numberline {1.2}Objectives}{3}{subsection.1.2}%
\contentsline {subsection}{\numberline {1.3}Biomarker Subgroups}{3}{subsection.1.3}%
\contentsline {section}{\numberline {2}Patient Demographics \& Biomarker Distribution}{3}{section.2}%
\contentsline {subsection}{\numberline {2.1}Baseline Characteristics}{3}{subsection.2.1}%
\contentsline {subsection}{\numberline {2.2}Biomarker Distribution}{3}{subsection.2.2}%
\contentsline {section}{\numberline {3}Patient Disposition}{3}{section.3}%
\contentsline {section}{\numberline {4}Efficacy Results}{4}{section.4}%
\contentsline {subsection}{\numberline {4.1}Objective Response Rate by Biomarker Subgroup}{4}{subsection.4.1}%
\contentsline {subsection}{\numberline {4.2}Progression-Free Survival}{5}{subsection.4.2}%
\contentsline {subsection}{\numberline {4.3}Overall Survival}{5}{subsection.4.3}%
\contentsline {subsection}{\numberline {4.4}Best Change in Target Lesion Size}{6}{subsection.4.4}%
\contentsline {section}{\numberline {5}Biomarker--Response Correlation Analysis}{6}{section.5}%
\contentsline {subsection}{\numberline {5.1}EGFR Mutation Subtype Analysis}{6}{subsection.5.1}%
\contentsline {subsection}{\numberline {5.2}PD-L1 as a Predictive Biomarker in EGFR-WT Patients}{7}{subsection.5.2}%
\contentsline {subsection}{\numberline {5.3}Cross-Biomarker Interaction}{7}{subsection.5.3}%
\contentsline {section}{\numberline {6}Clinical Implications \& Recommendations}{8}{section.6}%
\contentsline {subsection}{\numberline {6.1}Evidence Summary}{8}{subsection.6.1}%
\contentsline {subsection}{\numberline {6.2}Biomarker-Guided Treatment Algorithm}{8}{subsection.6.2}%
\contentsline {subsection}{\numberline {6.3}Recommendations for Continued Development}{8}{subsection.6.3}%
\contentsline {section}{\numberline {7}Statistical Methods}{9}{section.7}%
\contentsline {section}{\numberline {A}Appendix: Individual Patient Data}{10}{appendix.A}%