% Auto-generated clinical schematic
% Description: NSCLC patient cohort biomarker stratification: N=25 patients stratified by EGFR status and PD-L1 TPS into 4 subgroups with treatment assignment
\documentclass[border=10pt]{standalone}
\usepackage{tikz}
\usetikzlibrary{shapes.geometric, arrows.meta, positioning}
\begin{document}
\begin{tikzpicture}[
    node distance=1.5cm,
    startstop/.style={rectangle, rounded corners, minimum width=3cm,
                     minimum height=1cm, text centered, draw=black, fill=blue!10},
    process/.style={rectangle, minimum width=3cm, minimum height=1cm,
                   text centered, draw=black, fill=orange!10},
    decision/.style={diamond, minimum width=3cm, minimum height=1cm,
                    text centered, draw=black, fill=green!10},
    arrow/.style={thick,->,>=Stealth}
]
% Placeholder nodes — replace with actual clinical pathway
\node (start) [startstop] {Patient Cohort (N=25)};
\node (biomarker) [decision, below=of start] {EGFR Status?};
\node (egfrpos) [process, below left=of biomarker] {EGFR+ (n=11)};
\node (egfrneg) [process, below right=of biomarker] {EGFR- (n=14)};
\draw [arrow] (start) -- (biomarker);
\draw [arrow] (biomarker) -- node[anchor=east] {Positive} (egfrpos);
\draw [arrow] (biomarker) -- node[anchor=west] {Negative} (egfrneg);
\end{tikzpicture}
\end{document}
